introduction, alzheimers, disease, affects, brain, disrupting, memory, thinking, judgement, causing, everyday, life, studied, however, cure, onset, usually, age, affected, earlier, predictable, gene, traits, type, inheritable, affecting, members, generations, causes, genetic, knowledge, mechanisms, known, complex, growing, costs, related, caregiving, hospitalisation, example, population, ageing, patient, method, prevention, involved, diagnosing, include, mental, fortitude, impairment, tests, cerebrospinal, uid, analysis, post, mortem, tissue, examination, rst, dementia, decade, later, progressed, research, techniques, understanding, progression, used, involve, differential, expression, imaging, scans, searching, possible, drug, targets, studies, shed, progresses, bioinformatics, provides, analysing, relevant, pathways, contributing, discovering, mainly, based, samples, isolated, limiting, stages, microchips, enabling, multiple, providing, information, reaction, data, analysed, using, computer, algorithms, statistical, extract, behave, differently, diseased, healthy, numerous, conducted, insight, linked, availability, compatible, hypotheses, proposed, furthermore, submitted, quality, presentation, descriptions, analyses, possibly, offered, validation, condently, further, moreover, novel, overlap, background, biology, central, dogma, molecular, basics, writings, lesk, heinaru, otherwise, cited, states, transmits, deoxyribonucleic, acid, ribonucleic, protein, nucleic, carrier, cells, nor, solid, transmission, philippe, hup, via, wikimedia, commons, modied, sequence, alphabet, adenine, guanine, cytosine, thymine, nucleotides, complementary, pairing, form, hydrogen, bonds, connect, linear, strand, anti, parallel, oriented, opposite, forming, double, helix, named, positions, differences, specicity, regulatory, replicatory, synthesising, contain, splicing, transcribed, pre, mrna, excising, introns, exons, remain, untranscribed, qef, eukaryotes, split, segments, intervening, regions, called, expressed, [figure, directed, upstream, similarly, downstream, controlled, internal, regulate, regulation, repressing, meaning, product, binds, longer, therefore, lessening, activating, transcription, promoted, slightly, uracil, singlestranded, folded, structures, itself, messenger, premrna, synthesised, undergoes, excised, spliced, [fig, translation, amino, determined, corresponds, codon, making, possibilities, sets, represent, standard, translator, molecule, encounters, intra, cellular, inuences, ph, level, interactions, stranded, densely, orderly, packed, chromosomes, dependent, species, single, main, functions, trna, rrna, translate, specic, transfer, transports, ribosomes, ribosomal, correlates, purpose, native, determines, biochemical, vast, structural, membranes, organelles, catalytic, enzymes, hormones, control, requires, conditions, temperature, fold, spontaneously, respective, unfold, disordered, functionally, passive, process, denaturation, active, recovers, normal, restored, irreversible, natural, aggregation, insoluble, inactive, aggregates, being, discussed, below, commanding, organ, responsible, tasks, controlling, synchrony, separated, hemispheres, divided, regard, hippocampus, amygdala, associated, neurons, characterised, body, soma, input, dendrites, output, axon, connecting, synapse, feature, myelin, sheath, rapidness, functional, insulation, schematic, illustration, receives, coated, transporting, terminals, originates, alois, provided, detailed, extensive, documentation, female, showed, paranoid, symptomatology, disorders, disturbances, aggressiveness, crying, progressive, confusion, death, described, plaques, tangles, similar, published, specied, investigation, improved, reverse, reported, yearly, risk, factors, environment, smoking, obesity, sion, sporadic, although, identied, inheritance, allele, guarantee, development, familiar, symptoms, develop, mutations, presenilin, attribute, across, accounts, currently, presence, conrmed, established, biomarkers, including, amyloid, beta, tau, phospho, obtained, lumbar, punctures, invasive, painful, easily, obtainable, sensitive, addition, combined, identify, diagnosis, certainty, denitive, manifest, undetected, intervals, differ, individuals, depend, hypertension, depressive, chronic, psychological, stress, forgetfulness, unable, recognize, orientation, comprehension, unaware, date, language, communication, depression, aggression, severe, showing, shrinkage, cerebral, cortex, national, institute, aging, health, gressing, eventually, physical, abilities, needing, assistance, self, incapability, walking, difculties, swallowing, nally, ending, entorhinal, frontal, pathophysiological, abnormal, neurobrillary, neuronal, loss, atrophy, synaptic, dysfunction, neurodegeneration, assembly, stability, axonal, microtubules, hyperphosphorylated, results, disruption, cytoskeleton, formation, intracellular, located, surface, growth, adhesion, mobility, precursor, cleavage, producing, neurotoxic, peptides, adhere, extracellular, disintegrating, lose, connection, thereby, cleaved, thus, soluble, interdisciplinary, eld, combining, mathematics, statistics, science, aim, solve, biological, computational, resources, microarrays, designed, simultaneous, millions, arrangement, immobilised, probes, oligonucleotides, according, subsequent, experiment, designs, match, mismatch, section, occupies, selected, per, hybridizing, locations, length, manufacturer, array, hybridization, entails, binding, origins, synthetic, whereas, properties, ensuing, application, entirely, centre, mismatching, disrupt, negative, ization, capturing, non, theoretical, determining, reliability, commonly, manufactured, affymetrix, illumina, photochemical, synthesis, manufacturing, genechip, comparison, distinguishing, onto, accordance, intended, proling, genome, transcriptome, mapping, custom, genotyping, typically, capable, containing, silica, beads, copies, base, acting, highly, miniaturized, mm, elements, square, millimetre, localisation, identication, mentioned, hybridisation, involves, material, cdna, labelled, uorescently, washed, scanned, composite, image, created, colour, uorescent, labels, calculation, preprocessing, raw, inconsistencies, missing, values, cleaned, levelled, caused, precipitation, scanner, less, reliable, intensity, software, peculiarities, outliers, interfere, clustering, cleaning, levelling, meaningful, choose, suitable, amongst, pool, consider, objective, following, paragraphs, introduce, general, conventional, correcting, effects, batches, sex, collection, chemicals, humidity, scientist, doing, shown, biggest, impact, performance, normalization, median, centering, distributions, dataset, ensuring, comparability, comparable, summarization, reducing, volume, directly, implicitly, preserving, outcomes, respectively, measure, relation, robust, multi, average, corrected, suite, developed, global, adjustment, measurement, log, transformed, combination, polish, detection, subtracts, correction, tukey, biweight, estimator, variant, normalisation, summarisation, estimate, taking, advantage, conveyed, ratio, derived, calculate, produces, asymmetrical, regulated, represented, range, calculated, transformation, logarithm, freely, chosen, symmetric, innity, likewise, symmetrical, higher, lower, inverse, visualization, comprehend, produced, visualisation, construction, scatter, plots, informative, initial, evaluations, comparing, achieved, dividing, patterns, reduces, dimensionality, intuitive, user, visualising, clustered, heat, map, visual, observation, whether, visualise, heatmaps, networks, instance, scatterplots, boxplots, introduced, graphs, convey, mathematically, nodes, vertices, connected, correlation, coefcient, ordered, regulator, conveying, within, metabolic, modelling, metabolism, organisms, scope, thesis, focus, undirected, various, motifs, aforementioned, perform, relative, uri, alon, review, simple, feedforward, loop, module, dense, overlapping, regulon, additional, autoregulation, represses, positive, enhances, production, inuenced, enhancing, frequent, nregulate, diamond, feedback, article, sensory, responding, nutrient, developmental, guiding, differentiations, modication, suggesting, simplicity, random, scale, free, modularity, direct, indirect, existence, hubs, identiable, utopiawiki, remarkably, resistant, accidental, attacks, coordinated, pathogen, vulnerable, smallworld, tendency, having, shorter, expected, finally, refers, conceptually, performing, separable, system, contrast, coloured, matrix, representing, columns, corresponding, ordering, interpretation, proves, complicated, tend, retrieve, meanfigure, difcult, perceive, randomly, opencourseware, ingful, reordered, hierarchical, dendrogram, division, concept, arising, clusters, create, similarity, clear, depicting, irrelevant, rawlinson, mckay, ghuman, wellmann, ryan, prajaneh, zaman, hughes, kingsmill, metric, eucleidean, pearson, nding, closest, merging, calculating, repeating, iteratively, remove, furthest, resulting, geometrically, compact, centroids, useful, pairwise, nd, disproportionately, volcano, summary, roadnottaken, whiskers, multiplier, changed, original, robseb, databases, amount, regularly, updated, consistent, storage, fraction, uploaded, minimum, requirements, verication, guidelines, limited, omnibus, arrayexpress, share, public, repositories, throughput, recommended, scientic, journals, researchers, submit, sequencing, query, download, imports, weekly, basis, center, biotechnology, accommodates, pubmed, integrated, entrez, database, retrieval, access, genomic, ontology, annotation, terms, describing, assigned, categories, component, themselves, independent, hierarchically, organized, swissprot, genbank, interlinking, eliminate, dated, improving, daily, kyoto, encyclopedia, assisting, interpreting, essentially, offering, tools, enriched, reactome, peer, reviewed, expert, biologist, collaboration, vocabularies, literature, website, activities, representation, search, interacting, predicted, comprehensive, contained, text, scored, condence, graphics, computation, source, programming, graphical, bioconductor, project, relying, packages, platform, cytoscape, originally, matured, expanded, domains, le, javascript, plugins, google, scholar, restricting, summarized, goals, explore, expand, previous, approaches, previously, unused, ray, zhang, identifying, topology, regional, coexpression, temporal, gyrus, posterior, cingulate, jamal, colleagues, potential, wanted, improve, pathogenesis, sub, puthiyedth, signicant, yue, aimed, provid, credibility, hypothesised, underlying, degs, downloaded, zhao, male, signicantly, forabosco, leagues, analyse, wang, et, al, nineteen, uncover, roles, mirnas, acquaah, mensah, taylor, usefulness, situ, martinezballesteros, deeper, acquired, consisting, descision, quantitative, evaluate, extent, netwas, nevadoholgado, lovestone, hypothesis, steroidal, antiinammatory, nsaids, unrecognised, inammation, suppressing, hao, friedman, failed, clinical, trials, understand, compared, needed, hippcampus, collecting, slabs, accurate, efcient, laser, capture, microdissection, gather, surrounding, scrape, opposed, majority, suppressed, selection, pyramidal, occur, forebrain, abundance, cortical, suggest, involvement, cognitive, processing, regarding, mostly, humans, lab, bred, allen, atlas, breeding, enabled, variety, gender, retrieved, resolution, eichele, diez, roux, consisted, apoptosis, response, oxidative, superior, hippocampal, featured, minority, included, polymerase, chain, qrt, magnetic, resonance, positron, emission, tomography, varied, occurring, phases, alteration, revision, accumulation, assortment, learning, differed, analytic, popular, available, framework, spanned, corroborating, versatility, limma, andsiggenes, thelimma, seq, technologies, reading, exploring, siggenespackage, signicance, empirical, bayes, differentially, class, expressing, feng, reduced, larger, relatively, zang, signatures, retain, ranked, degree, computed, marking, scoring, separately, applied, acquire, rankprod, genemeta, ranking, parison, false, discovery, rate, meta, written, integrate, detect, co, obtain, association, scores, link, bayesian, weighted, martinez, ballesteros, garnet, presented, integration, classication, percentage, correctly, classied, threshold, congurations, executed, accuracy, extracted, eleven, predict, naive, net, decision, hybrid, classier, locally, nearest, neighbour, logistic, regression, support, vector, generate, training, models, cross, averaged, generated, prioritize, prioritised, online, mendelian, newly, composed, constructed, mathematical, comprising, partial, equations, simulate, multiplication, uniformity, formed, comprised, successive, nevado, holgado, fuzzy, logic, boolean, operator, blood, induced, derivations, mention, dysregulations, suppression, enrichment, subset, ve, underwent, topological, select, interest, employed, linkage, dynamically, engineering, transcriptional, ensemble, visualised, ingenuity, connectivity, collected, extraction, considered, experimentally, validated, construct, selecting, utilized, clusterone, density, restricted, procured, overrepresented, measuring, operation, simulation, gosim, chose, relevance, statistically, genego, metacore, ample, discarding, etc, throughout, essential, importance, claim, null, cutoff, rejecting, failing, reject, uneven, bonferroni, testing, discarded, smaller, benjamini, hochberg, fishers, mann, whitney, student, displayed, built, visualized, exhibit, exhibiting, characteristics, web, gure, featuring, obtaining, biomolecule, absolute, display, overexpression, interim, mixture, spearman, assessment, dissimilarity, dynamic, cutting, dened, adjacency, probesets, distinguish, assays, axis, signies, horisontal, separates, insignicantly, dots, considering, supplementary, summarised, thirteen, investigational, inhibited, proven, correlated, uncovered, therapeutic, examine, severely, indicated, mediating, changing, microglial, genetically, implicated, vulnerability, demonstrate, capability, unique, threegene, implication, diet, integrating, successful, characterisation, ninety, phenotype, prioritization, performed, identifyed, challenge, solutions, strength, indirectly, suggestion, current, efcacy, therapy, hippo, campal, authors, hong, bo, yang, fang, xiao, li, hu, fan, bin, kong, etm, experimental, medicine, pages, rapid, concentrating, details, accession, plus, medial, primary, screening, lter, genelter, matching, pf, applying, compare, secondly, identies, submodules, normalised, ltering, binomial, probability, estimation, followed, fth, tting, parameters, shortest, existing, taken, greatest, decreasing, proteasome, oxydative, phosphorylation, parkinsons, huntingtons, closing, remarks, essence, carefully, greater, exhibited, inherent, trends, counting, evidence, complexity, stated, pressing, reversion, corroborates, overlooking, unclear, lacking, conclusion, overview, approached, combine, adresses, intricacies, appeared, reconstruction, view, discrepancies, detected, unambiguous, noticed, indicates, necessity, benet, reports, grasp, mechanics